Endocrine Abstracts

Introduction Thyroid cancer (TC) is rare in childhood. The aim of the present study was to describe the tumoral characteristics of children and adolescents with TC and to investigate the frequency of microcarcinomas in that population.Methods We studied the medical records of 101 children and adolescents (≤ 21 years-old) who were diagnosed with TC between January 1977 and December 2011 in Theagenio Cancer Hospital. The following characteristics wer...

Metabolic syndrome (MetS) is a condition characterized by abdominal obesity, insulin resistance, dyslipidaemia and hypertension, that is associated with cardiovascular disease and inflammatory metabolic disorders. This study aimed to ascertain the effect of selected parameters of purinergic and cholinergic systems in lymphocytes of MetS patients. The adenosine deaminase (ADA), dipeptidyl peptidase IV (DPP-IV) and acetylcholinesterase (AChE) activities, as well as γ-glutam...

Introduction: TSH-secreting pituitary adenomas (TSHoma) are rare. Epidemiological data are scant and there are no reports on national incidence. The aim of this study was to estimate the national incidence and prevalence of TSHomas in Sweden.Methods: This is an observational study from all tertial referral centers where the Swedish Pituitary Registry and WHO ICD coding were used to identify patients diagnosed with TSHomas in Sweden 1990–2010. Medica...

Introduction and Aims: Graves’ disease (GD) is mediated by thyroid stimulating antibodies (TSAbs) to the TSH receptor (TSHR). Treatments for GD have remained unchanged for more than 40 years with less than 50% of patients achieving long term remission with medical therapy. Experimental animal models have been described which facilitate understanding of disease mechanisms and permit studies of novel immunotherapeutic interventions. However studies aiming to perturb the Th1...

Introduction: There is no published data on dispensed drug pattern in patients with Autoimmune Addison’s disease (AAD). Sweden has excellent condition for research in this area, with high-quality population based registers. Among them is the Swedish Prescribed Drug Register (SPDR) that contains information about dispensed prescribed drugs. By linking registry data, we aimed at accurately estimate the prevalence and incidence of AAD, the prevalence of common concomitant au...

Background: Recent studies show that Infliximab (IFX), an antibody against tumour necrosis factor α (TNFα), may improve growth in children with Crohn’s disease (CD). These studies have not adequately addressed the concomitant factors such as medication, nutrition and puberty that may also improve growth.Methods: Retrospective study of 22 children (13 M) with CD, median age at start of IFX 13.2 years (7.4, 16.1) with auxology at 6 months be...

Obesity is associated with decreased hepatic reactivation of glucocorticoids (Gc) by 11β-hydroxysteroid dehydrogenase type 1 (11HSD) and increased metabolism of glucocorticoids by hepatic A-ring reductases, which may contribute to activation of the hypothalamic-pituitary-adrenal axis. Androgen action encourages central obesity and increased metabolic complications, possibly by altering Gc metabolism.This study investigates the role of gonadal androg...

Background: Recent studies show that infliximab (IFX), an antibody against tumour necrosis factorα (TNFα), may improve growth in children with Crohn’s disease (CD). These studies have not adequately addressed the concomitant factors such as medication, nutrition and puberty that may also improve growth.Methods: Retrospective study of 22 children (13M) with CD, median age at start of IFX 13.2 years (7.4, 16.1) with auxology at 6 months befo...

Background: Patients with an insulinoma are at variable risk of severe hypoglycemia due to wide ranges of both tumoral insulin secretion and peripheral tissue sensitivity to chronic hyperinsulinaemia.Objectives: In this study we investigated the clinical, biological and tumoral characteristics of a large series of patients with immunohistochemically confirmed insulinoma and we assessed both insulin sensitivity and beta-cell function in fasting steady-sta...

We have shown that repeated cold stress increases ovarian sympathetic tonus and induces typical polycystic ovary syndrome (PCOS) features. Lesion of the noradrenergic nucleus Locus Coeruleus decreases ovarian noradrenaline release and prevents stress-induced PCOS in rats exposed to chronic intermittent cold stress. The aim of this study was to assess whether the alterations on ovarian morphology, ovulation rate and hormonal secretion induced by cold stress could be prevented b...